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SAINING Bak (D4E4) Rabbit mAb (SAINING UV375 Conjugate)
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Detailed Information
Description Bak (D4E4) Rabbit mAb (SAINING  UV375 Conjugate) 
Item number 8092012
specification 50 μg
Price US$ 880.00
Description

Supporting Data

REACTIVITY H M R Mk
SENSITIVITY Endogenous
MW (kDa)
Source/Isotype Rabbit IgG
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Mk-Monkey 

Product Information

Product Description

SAINING antibody is conjugated to  UV375 fluorescent dye under optimal conditions and formulated at 200 µg/mL. This antibody conjugate is expected to exhibit the same species cross-reactivity as the unconjugated 

Product Usage Information

SAINING conjugates are produced using highly validated SAINING primary antibodies and conjugation methods that have been rigorously tested, ensuring high-quality conjugates and lot-to-lot consistency. These conjugates are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity. However, they are not tested on specific assays.

Optimal dilutions/concentrations should be determined by the end user. When performing flow cytometry, we recommend using an isotype control conjugate at the same concentration as the antibody conjugate.

Storage

Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.

Specificity / Sensitivity

Bak (D4E4) Rabbit mAb (SAINING  UV375 Conjugate) recognizes endogenous levels of total Bak protein.

Species Reactivity:

Human, Mouse, Rat, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly75 of human Bak protein.

Background

Bak is a proapoptotic member of the Bcl-2 family (1). This protein is located on the outer membrane of mitochondria and is an essential component for transduction of apoptotic signals through the mitochondrial pathway (2,3). Upon apoptotic stimulation, an upstream stimulator like truncated BID (tBID) induces conformational changes in Bak to form oligomer channels in the mitochondrial membrane for cytochrome c release. The release of cytochrome c to the cytosol activates the caspase-9 pathway and eventually leads to cell death (4,5).
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Efforts to build a high-end brand of laboratory consumables.
SAINING was established in May 2018, settled in Taizhou (Xianju) Medical Device Industrial Park in February 2019, and established SAINING (Suzhou) Biotechnology Co., Ltd. in March 2020. We are a biological laboratory consumables manufacturer integrating R&D, production and sales.

Since its establishment, the company has developed rapidly and now has a 100,000-level purification workshop of 15,000 square meters, a factory area of 30,000 square meters, a Suzhou technology research and development center, a Suzhou production base and a Taizhou production base. The main products include cell culture, biological detection liquid processing, medical equipment, safety protection, etc., which can be widely used in testing institutions (IVD), biological research, medical treatment, new drug research and development, laboratory scientific research and other fields. The product has performance and high quality. After testing by third-party testing agencies and relevant scientific research units, it has the ability to replace high-quality imported products.
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